Two oral dosages—choose an appropriate next step for her1

Based on the severity of symptoms and treatment objectives, use the lowest effective dose of ORILISSA1

The dose-dependent efficacy and safety results of ORILISSA along with the severity of symptoms and treatment objectives can help you choose the right dosage for your individual patients



A next step that’s designed to fit into her life


ORILISSA 150 mg QD Packaging1

Use for longer than 24 months not recommended

ORILISSA 150 mg QD monthly carton packaging

At home | Monthly carton NDC 0074-0038-28

ORILISSA 150 mg QD weekly blister packaging

On-the-go | Weekly blister pack

Packaging shown is not actual size
Monthly carton contains 4 weekly blister packs


One tablet taken once a day

AM or PM

ORILISSA 150 mg QD oral tablet

At approximately the same time each day,
with or without food


Tablets shown are not actual size


Pink check mark

Dysmenorrhea



Pink check mark

Non-menstrual Pelvic Pain (NMPP)



ORILISSA 200 mg BID Packaging1

Use for longer than 6 months not recommended

ORILISSA 200 mg BID monthly carton packaging

At home | Monthly carton NDC 0074-0039-56

ORILISSA 200 mg BID weekly blister packaging

On-the-go | Weekly blister pack

Packaging shown is not actual size
Monthly carton contains 4 weekly blister packs


One tablet taken twice a day; total of 400 mg a day

AM and PM

ORILISSA 200 mg oral tablet

At approximately the same time each day, with or without food


Tablets shown are not actual size


yellow checkmark

Dysmenorrhea



yellow checkmark

Non-menstrual Pelvic Pain (NMPP)



yellow checkmark

Dyspareunia




Help her take a next step in moderate to severe endometriosis pain treatment


Dosing and administration1

  • Exclude pregnancy before starting ORILISSA or start ORILISSA within 7 days from the onset of menses
  • Take ORILISSA orally at approximately the same time each day, with or without food
  • Based on the severity of symptoms and treatment objectives, use the lowest effective dose
  • Recommended Dosage: Duration of use is limited due to concerns about bone loss

    RECOMMENDED DOSAGE AND DURATION OF USE



Missed dose¹

  • If a woman misses a dose of ORILISSA, she should be instructed to take it as soon as she remembers as long as it is on the same day. She should then resume the regular dosing schedule
    • 150 mg once a day: no more than 1 tablet each day should be taken
    • 200 mg twice a day: no more than 2 tablets each day should be taken

Contraindications1

  • ORILISSA is contraindicated in women:
    • Who are pregnant. Exposure to ORILISSA early in pregnancy may increase the risk of early pregnancy loss
    • With known osteoporosis because of the risk of further bone loss
    • With severe hepatic impairment because of the risk of bone loss
    • With concomitant use of strong organic anion transporting polypeptide (OATP) 1B1 inhibitors (e.g., cyclosporine and gemfibrozil)