Pharmacology of ORILISSA

Discover reversible and dose-dependent hormone suppression1,2*†

Suppression of LH and FSH within 4-6 hours1,2*



Hormone suppression1-4*†


Luteinizing Hormone (LH)


Luteinizing hormone suppression four to six hours after a single dose

Follicle-Stimulating Hormone (FSH)


Follicle-stimulating hormone suppression four to six hours after a single dose

  • GnRH receptor antagonism leads to a dose-dependent suppression of LH and FSH1-3
  • Starting at 4-6 hours after administration of a single dose of ORILISSA, a decline in LH and FSH can be seen1

*Does not imply onset of efficacy during this time.

†For illustrative purposes only. LH and FSH levels and individual responses may vary




Dose-dependent suppression of estradiol1-3*†


Dose-dependent degree of estradiol suppression 24 hours after a single dose hormone suppression four to six hours after a single dose

  • After approximately 24 hours, subsequent suppression of estradiol levels occurs1-2*
  • The degree of suppression is dependent on the dose of ORILISSA1

*Does not imply onset efficacy during this time.


†Average 28 day cycle is for illustrative purposes only. Estradiol levels can vary throughout the cycle and Individual responses may vary. 21 day results have been extrapolated to 28 days.