Women with unresolved or recurrent endometriosis pain post surgery may benefit
from an alternate approach to help achieve pain relief
Endometriosis is a chronic, progressive disease and patients in debilitating pain should be treated with urgency6-9
Consider an alternate approach earlier for the pain reduction she needs
Suppressing estrogen is 1 way to effectively manage the pain of endometriosis, an estrogen-driven disease12
*Based on a cross-sectional, questionnaire-based survey among women with laparoscopically and/or histographically diagnosed endometriosis treated in 12 tertiary care centers in 10 countries.
†From a survey about the lifetime treatment experiences of 1160 women with surgically diagnosed endometriosis. The objective of this study was to report on the lifetime therapeutic practices and effectiveness of medical, surgical, and alternative treatments for endometriosis from the patients' perspective.
ORILISSA® (elagolix) is indicated for the management of moderate to severe pain associated with endometriosis.
These are not all the possible side effects of ORILISSA.
Safety and effectiveness of ORILISSA in patients less than 18 years of age have not been established.
US-ORIL-200330
For more information, please click here for full Prescribing Information.
1. ORILISSA [package insert]. North Chicago, IL: AbbVie Inc. 2. Sinaii N, Cleary SD, Younes N, Ballweg ML, Stratton P. Treatment utilization for endometriosis symptoms: a cross-sectional survey study of lifetime experience. Fertil Steril. 2007;87(6):1277-1286. 3. De Graaff AA, D'Hooghe TM, Dunselman GAJ, et al. The significant effect of endometriosis on physical, mental and social wellbeing: results from an international cross-sectional survey. Hum Reprod. 2013;28(10):2677-2685. 4. Data on file. In Play Analytics; May 2020. 5. American College of Obstetricians and Gynecologists. Frequently asked questions. FAQ013. Gynecologic problems. https://www.acog.org/patient-resources/faqs/gynecologic-problems/endometriosis. Updated October 2012. Accessed January 8, 2020. 6. American College of Obstetricians and Gynecologists. Practice bulletin no. 114: management of endometriosis. Obstet Gynecol. 2010;116(1):223-236. 7. Practice Committee of the American Society for Reproductive Medicine. Treatment of pelvic pain associated with endometriosis: a committee opinion [published correction appears in Fertil Steril. 2015;104(2):498]. Fertil Steril. 2014;101(4):927-935. 8. Agarwal SK, Chapron C, Giudice LC, et al. Clinical diagnosis of endometriosis: a call to action. Am J Obstet Gynecol. 2019;220(4):354.e1-354.e12. 9. Asante A, Taylor RN. Endometriosis: the role of neuroangiogenesis. Ann Rev Physiol. 2011;73:163-182. 10. Casper RF. Introduction: a focus on the medical management of endometriosis. Fertil Steril. 2017;107(3):521-522. 11. Fourquet J, Gao X, Zavala D, et al. Patients' report on how endometriosis affects health, work, and daily life. Fertil Steril. 2010;93(7):2424-2428. 12. Fischer JR. APGO Educational Series on Women's Health Issues. Diagnosis & management of endometriosis: pathophysiology to practice. Association of Professors of Gynecology and Obstetrics; 2012. 13. Barbieri RL. Endometriosis and the estrogen threshold theory. Relation to surgical and medical treatment. J Reprod Med. 1998;43(suppl 3):287-292.
ORILISSA® (elagolix) is indicated for the management of moderate to severe pain associated with endometriosis. Limit the duration of use based on the dose and coexisting condition.
These are not all the possible side effects of ORILISSA.
Safety and effectiveness of ORILISSA in pediatric patients have not been established.
US-ORIL-210045
For more information, please click here for full Prescribing Information.
1. ORILISSA [package insert]. North Chicago, IL: AbbVie Inc. 2. Sinaii N, Cleary SD, Younes N, Ballweg ML, Stratton P. Treatment utilization for endometriosis symptoms: a cross-sectional survey study of lifetime experience. Fertil Steril. 2007;87(6):1277-1286. 3. De Graaff AA, D'Hooghe TM, Dunselman GAJ, et al. The significant effect of endometriosis on physical, mental and social wellbeing: results from an international cross-sectional survey. Hum Reprod. 2013;28(10):2677-2685. 4. Data on file. In Play Analytics; May 2020. 5. American College of Obstetricians and Gynecologists. Frequently asked questions. FAQ013. Endometriosis. https://www.acog.org/womens-health/faqs/endometriosis?utm_source=redirect&utm_medium=web&utm_campaign=int. Updated February 2021. Accessed March 22, 2021. 6. American College of Obstetricians and Gynecologists. Practice bulletin no. 114: management of endometriosis. Obstet Gynecol. 2010;116(1):223-236. 7. Practice Committee of the American Society for Reproductive Medicine. Treatment of pelvic pain associated with endometriosis: a committee opinion [published correction appears in Fertil Steril. 2015;104(2):498]. Fertil Steril. 2014;101(4):927-935. 8. Agarwal SK, Chapron C, Giudice LC, et al. Clinical diagnosis of endometriosis: a call to action. Am J Obstet Gynecol. 2019;220(4):354.e1-354.e12. 9. Asante A, Taylor RN. Endometriosis: the role of neuroangiogenesis. Ann Rev Physiol. 2011;73:163-182. 10. Casper RF. Introduction: a focus on the medical management of endometriosis. Fertil Steril. 2017;107(3):521-522. 11. Fourquet J, Gao X, Zavala D, et al. Patients' report on how endometriosis affects health, work, and daily life. Fertil Steril. 2010;93(7):2424-2428. 12. Fischer JR. APGO Educational Series on Women's Health Issues. Diagnosis & management of endometriosis: pathophysiology to practice. Association of Professors of Gynecology and Obstetrics; 2012. 13. Barbieri RL. Endometriosis and the estrogen threshold theory. Relation to surgical and medical treatment. J Reprod Med. 1998;43(suppl 3):287-292.
*Assessed from baseline to the analysis month greater or equal to the following calculated, threshold of improvement in pain score in each study: Dysmenorrhea responder thresholds were ≥0.81-point decrease from baseline in ELARIS EM-1 and ≥0.85-point decrease from baseline in ELARIS EM-2. NMPP responder thresholds were ≥0.36-point decrease from baseline in ELARIS EM-1 and ≥0.43-point decrease from baseline in ELARIS EM-2. The threshold was determined based on analysis of the change in pain score corresponding to "much improved" or "very much improved" on the Patient Global Impression of Change Questionnaire.
†Baseline and monthly visit values were based on a 35-day mean.
*Dysmenorrhea responder threshold was ≥0.81-point decrease from baseline in ELARIS EM-1 and ≥0.85-point decrease from baseline in ELARIS EM-2. NMPP responder threshold was ≥0.36-point decrease from baseline in ELARIS EM-1 and ≥0.43-point decrease from baseline in ELARIS EM-2.
†In ELARIS EM-1 and EM-2, the mean changes in dysmenorrhea and NMPP scores from baseline to month 6 were secondary endpoints.
‡In ELARIS EM-1 and EM-2, the mean changes in dysmenorrhea and NMPP scores from baseline to each month (except month 6) were non-ranked secondary endpoints. Appropriate multiplicity adjustments were not applied.
§Baseline and monthly visit values were based on a 35-day mean.
*Assessed from baseline to the analysis month greater or equal to the following calculated, threshold of improvement in pain score in each study: Dysmenorrhea responder thresholds were ≥0.81-point decrease from baseline in ELARIS EM-1 and ≥0.85-point decrease from baseline in ELARIS EM-2. NMPP responder thresholds were ≥0.36-point decrease from baseline in ELARIS EM-1 and ≥0.43-point decrease from baseline in ELARIS EM-2. The threshold was determined based on analysis of the change in pain score corresponding to "much improved" or "very much improved" on the Patient Global Impression of Change Questionnaire.
†Baseline and monthly visit values were based on a 35-day mean.
*Assessed from baseline to the analysis month greater or equal to the following calculated, threshold of improvement in pain score in each study: Dysmenorrhea responder thresholds were ≥0.81-point decrease from baseline in ELARIS EM-1 and ≥0.85-point decrease from baseline in ELARIS EM-2. NMPP responder thresholds were ≥0.36-point decrease from baseline in ELARIS EM-1 and ≥0.43-point decrease from baseline in ELARIS EM-2. The threshold was determined based on analysis of the change in pain score corresponding to "much improved" or "very much improved" on the Patient Global Impression of Change Questionnaire.
†Baseline and monthly visit values were based on a 35-day mean.