For 15 years, I suffered through painful periods, pain with sex, and severe pelvic pain. It's important for women like me to feel like they can speak up."
Shawna K.
There has been a change to the Prescribing Information. Click here to see the changes and talk with your doctor for more information.
>Endometriosis is a chronic and painful disease that is more common than you might think. Here’s a quick refresher on the inner workings of endometriosis.
Endometriosis occurs when endometrium (tissue that acts like the lining of your uterus) starts growing outside of your uterus, where it doesn’t belong.
The endometrial-like tissue that grows outside of your uterus is called a lesion or an implant.
When estrogen levels rise, these lesions (patches of endometrial-like tissue) can grow. Later in the menstrual cycle, they may break down and shed. This can cause pain throughout the month.
These lesions are fueled by a sex hormone called estrogen.
The location of lesions can affect symptoms, but the extent of the disease doesn't necessarily relate directly to
the level of pain experienced.
Though the exact cause of endometriosis is unknown, most scientists think it relates to a process called retrograde menstruation. That’s when tissue that lines the inside of your uterus flows out in the wrong direction—through your fallopian tubes—during your period. The out-of-place tissue can cause pain and inflammation as it starts growing on surfaces and organs in your pelvic region.
There are other possible theories as to what can cause endometriosis, such as:
Some lesions can even form their own nerves or scar tissue (called adhesions) between organs, which can cause pain. Although rare, lesions are sometimes found in areas further away from the pelvic area.
For 15 years, I suffered through painful periods, pain with sex, and severe pelvic pain. It's important for women like me to feel like they can speak up."
Shawna K.
Endometriosis is sometimes categorized into 4 stages (from 1, which is minimal, to 4, which is severe). Each stage is based on location, amount, depth, and size of lesions. The pain associated with endometriosis may not be related to the stage of the disease. For example, a woman with Stage 1 of endometriosis could have significant pain or very mild pain.
ORILISSA is a pill developed for the management of moderate to severe endometriosis pain.
Learn moreWant to know how ORILISSA works? Watch a video to learn more about how ORILISSA works in your body.
Watch videoThink ORILISSA may be right for you? It’s time to talk to your gynecologist! Create a guide to help you explain your pain more easily at your next gynecologist's appointment.
Explain your painORILISSA® (elagolix) is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if ORILISSA is safe and effective in children under 18 years of age.
ORILISSA may cause serious side effects, including bone loss and effects on pregnancy:
Tell your HCP about all of your medical conditions, including if you:
Tell your HCP about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your HCP if you take birth control pills. Your HCP may advise you to change the pills you take or your method of birth control.
ORILISSA can cause serious side effects including:
The most common side effects of ORILISSA include: hot flashes or night sweats, headache, nausea, difficulty sleeping, absence of periods, anxiety, joint pain, depression, and mood changes.
These are not all of the possible side effects of ORILISSA. This is the most important information to know about ORILISSA. For more information, talk to your doctor or HCP.
Take ORILISSA exactly as your HCP tells you. Tell your HCP if you have any side effect that bothers you or that does not go away. Call your HCP for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.
If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.
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Please click here for Full Prescribing Information and Medication Guide.