ORILISSA is a daily pill — available in 2 doses:


One pill taken once a day, at about the same time, with or without food

ORILISSA® (elagolix) 150 mg daily dose



One pill taken twice a day, for a total of 400 mg a day, at about the same time each day, with or without food

ORILISSA (elagolix) 200 mg twice daily dose
ORILISSA (elagolix) 200 mg twice daily dose


Your doctor will recommend the lowest effective dose based on your symptoms and treatment goals. Both the pain relief and any side effects you may experience could be different, depending on the dose you take and how your body responds.

Because ORILISSA works throughout your menstrual cycle, it’s important to take ORILISSA every day, exactly as your doctor prescribed—even if you’re feeling better. ORILISSA is not a medication you take only as needed.

It does not contain hormones and does not prevent pregnancy.

What should I tell my doctor before taking ORILISSA?

Before you take ORILISSA, tell your doctor about all of your medical conditions, including if you:

  • have or have had broken bones
  • have other conditions or take medications that may cause bone problems
  • have or have had depression, mood problems or suicidal thoughts or behavior
  • have liver problems
  • think you may be pregnant. You should avoid becoming pregnant while taking ORILISSA
  • are breastfeeding or plan to breastfeed. It is not known if ORILISSA passes into your breastmilk. Talk to your doctor about the best way to feed your baby if you take ORILISSA.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your doctor if you take birth control pills. Your doctor may advise you to change the pills you take, or your method of birth control.

Know the medicines you take. Keep a list of your medicines with you to show to your doctor and pharmacist when you get a new medicine.

Don’t take ORILISSA if you:

  • are or may be pregnant
  • have osteoporosis
  • have severe liver disease
  • are taking medicines known as strong OATP1B1 inhibitors such as cyclosporine or gemfibrozil.  Ask your doctor if you are not sure if you are taking one of these medicines.

When can I expect to feel relief for my endo pain?

  • ORILISSA starts working in the body to lower estrogen after about 24 hours; however, pain relief will take longer.
  • It may take 3 months to experience the full benefits of endo pain relief.

Other quick answers and tips

If you miss a dose, take it as soon as you remember as long as it is on the same day. You should then continue your regular dosing schedule.

(one pill taken once a day)

Do not take more than 1
pill each day.

(one pill taken twice a day)

Do not take more than 2 pills
(400 mg total) each day.

If you take too much ORILISSA, call your doctor or go to the nearest hospital.

ORILISSA can be taken with or without food.

ORILISSA does not prevent pregnancy. You'll need to use effective methods of birth control while taking ORILISSA, and for 1 week after you stop taking ORILISSA. So talk to your doctor about which birth control to use. Your doctor may change the birth control you were on before you start taking ORILISSA.

Birth control pills that contain estrogen may make ORILISSA less effective. It is not known how well ORILISSA will work while you are taking progestin-only birth control.

Store ORILISSA between 36°F to 86°F (2°C to 30°C). Keep ORILISSA and all medicines out of the reach of children.

If your doctor prescribed you ORILISSA 200 mg, take one ORILISSA 200 mg pill in the morning and one ORILISSA 200 mg pill in the evening (400 mg total).

Questions? Keep ’em coming

If you’ve still got questions about ORILISSA, you can:

  • Give us a call at 1-844-OriForMe (1-844-674-3676). We’re here to answer questions you may have about ORILISSA
    • We're available Monday through Friday from 9 AM - 9 PM ET
    • For questions outside these hours, you can find some answers to common questions about ORILISSA right here on the site
  • Get the Ori for Me® app (for iOS or for Android). The Ori for Me app offers communication, wellness tips, and life hacks for women living with endometriosis
  • Always ask your doctor. He or she knows you the best, and can help find the answers you’re looking for

Need help starting the conversation with your doctor?

Rate your pain so you can have a more informed conversation with your doctor at your next appointment.