ORILISSA is a daily pill — available in 2 doses tailored to your treatment goals.


One pill taken once a day, at about the same time each day, with or without food



One 200 mg pill taken twice daily (total of 400 mg), at about the same times each day, with or without food



Your gynecologist will recommend the lowest effective dose tailored to meet your individual treatment needs. Both the pain relief and any side effects you may experience could be different, depending on the dose you take and how your body responds.

Because ORILISSA works throughout your menstrual cycle, it’s important to take ORILISSA every day, exactly as your gynecologist prescribed—even if you’re feeling better. ORILISSA is not a medication you take only as needed.

ORILISSA does not contain hormones and does not prevent pregnancy.

Now you know how to take ORILISSA. But what if you want to stop?

ORILISSA is a daily pill, so you and your gynecologist can decide to stop using it at any time.

You may not get your period while taking ORILISSA, since it lowers estrogen. However, this does not mean ORILISSA will put you into early menopause. As a matter of fact, the majority of women (~60%) in clinical trials who took either dose of ORILISSA got their period within a month after they stopped taking ORILISSA. And about 95% got their period within 6 months.*

*These women had taken ORILISSA for 6 months.

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Got questions? We've got answers.

  • ORILISSA starts working in the body to lower estrogen after about 24 hours; however, pain relief will take longer
  • It may take 3 months to experience the full benefits of endometriosis pain relief