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HOW TO TAKE ORILISSA


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ORILISSA is a daily oral pill – available in 2 doses:

ORILISSA 150 mg

One pill taken once a day, at about the same time each day, with or without food

ORILISSA™ (elagolix) 150 mg daily dose

OR

ORILISSA 200 mg

One pill taken twice a day, for a total of 400 mg a day, at about the same time each day, with or without food

ORILISSA™ (elagolix) 200 mg twice daily dose

AND


Pills pictured are not actual size.


It’s important to take ORILISSA every day, exactly as your doctor tells you to take it—even when you are feeling better. ORILISSA is not a medication you take only as needed. ORILISSA is not birth control. It does not prevent pregnancy.

Before you take ORILISSA, tell your doctor about all of your medical conditions, including if you:

  • have or have had broken bones
  • have other conditions or take medications that may cause bone problems
  • have or have had depression, mood problems or suicidal thoughts or behavior
  • have liver problems
  • think you may be pregnant. You should avoid becoming pregnant while taking ORILISSA
  • are breastfeeding or plan to breastfeed. It is not known if ORILISSA passes into your breastmilk. Talk to your doctor about the best way to feed your baby if you take ORILISSA.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your doctor if you take:

  • birth control pills. Your doctor may advise you to change the pills you take, or your method of birth control.

Know the medicines you take. Keep a list of your medicines with you to show to your doctor and pharmacist when you get a new medicine.

Your doctor will give you a pregnancy test before you start taking ORILISSA or will have you start taking ORILISSA within 7 days after you start your period.

Don’t take ORILISSA if:

You are or may be pregnant, have osteoporosis, have severe liver disease, or are taking medicines known as strong OATP1B1 inhibitors such as cyclosporine or gemfibrozil. Ask your doctor if you are not sure if you are taking one of these medicines.

Things to know while taking ORILISSA

If you think you are pregnant, stop taking ORILISSA immediately and talk to your doctor.

Menstrual bleeding ORILISSA may change your menstrual periods (irregular bleeding or spotting, a decrease in menstrual bleeding, or no bleeding at all), making it hard to know if you are pregnant. Watch for other signs of pregnancy such as breast tenderness, weight gain and nausea.
Birth control ORILISSA does not prevent pregnancy and is not birth control. You will need to use effective methods of birth control that do not contain hormones such as condoms or spermicide while taking ORILISSA and for one week after you stop taking ORILISSA. Birth control pills that contain estrogen may make ORILISSA less effective. It is not known how well ORILISSA will work while you are taking progestin-only birth control such as injections or implants.

Talk to your doctor about which birth control to use during treatment with ORILISSA. Your doctor may change the birth control you were on before you start taking ORILISSA.
Breast feeding It is not known if ORILISSA passes into breastmilk. Talk to your doctor about the best way to feed your baby if you take ORILISSA.
ORILISSA and food ORILISSA can be taken with or without food.
Storage and handling ORILISSA should be stored between 36°F to 86°F (2°C to 30°C). Keep ORILISSA and all medicines out of the reach of children.

Missed dose?

If you miss a pill, take it as soon as you remember, as long as it is on the same day.

ORILISSA 150 mg (once a day) Do not take more than 1 pill each day.
ORILISSA 200 mg (twice a day) Do not take more than 2 pills (400 mg total) each day

If you take too much ORILISSA, call your doctor or go to the nearest hospital.