ORILISSA is a daily pill — available in 2 doses:


One pill taken once a day, at about the same time each day, with or without food

ORILISSA® (elagolix) 150 mg daily dose



One pill taken twice a day, for a total of 400 mg a day, at about the same time each day, with or without food

ORILISSA (elagolix) 200 mg twice daily dose
ORILISSA (elagolix) 200 mg twice daily dose


Your gynecologist will recommend the lowest effective dose based on your symptoms and treatment goals. Both the pain relief and any side effects you may experience could be different, depending on the dose you take and how your body responds.

Because ORILISSA works throughout your menstrual cycle, it’s important to take ORILISSA every day, exactly as your gynecologist prescribed—even if you’re feeling better. ORILISSA is not a medication you take only as needed.

It does not contain hormones and does not prevent pregnancy.

Now you know how to take ORILISSA. But what if you want to stop?

ORILISSA is a daily pill, so you and your gynecologist can decide to stop using it at any time.

The majority of women in clinical trials* who took either dose of ORILISSA got their period within a month after they stopped taking it (~60%, and ~95% got it within 6 months).

*These women had taken ORILISSA for 6 months.

Got questions? We've got answers.

  • ORILISSA starts working in the body to lower estrogen after about 24 hours; however, pain relief will take longer.
  • It may take 3 months to experience the full benefits of endometriosis pain relief.

Take it as soon as you remember so long as it's still the same day. And then the next day, simply get back on schedule and take ORILISSA at the same time you usually do.

(one pill taken once a day)

Do not take more than 1
pill each day.

(one pill taken twice a day)

Do not take more than 2 pills
(400 mg total) each day.

If you take too much ORILISSA, call your gynecologist or go to the nearest hospital.

ORILISSA can be taken with or without food. In other words, you do you!

ORILISSA does not prevent pregnancy. You'll need to use effective methods of birth control while taking ORILISSA, and for 1 week after you stop taking ORILISSA. Birth control pills that contain estrogen may make ORILISSA less effective. It is not known how well ORILISSA will work while you are taking progestin-only birth control.

So talk to your gynecologist about which birth control to use. She or he may change your birth control before you start taking ORILISSA.

Store ORILISSA between 36°F to 86°F (2°C to 30°C). Keep ORILISSA and all medicines out of the reach of children.

If your gynecologist prescribed you ORILISSA 200 mg, take one ORILISSA 200 mg pill in the morning and one ORILISSA 200 mg pill in the evening (400 mg total).

Still got questions? Keep 'em coming

If you’ve still got questions about ORILISSA, you can:

  • Give us a call at 1-844-OriForMe (1-844-674-3676). We’re here to answer questions you may have about ORILISSA
    • We're available Monday through Friday from 9 AM - 9 PM ET
    • For questions outside these hours, you can find some answers to common questions about ORILISSA right here on the site
  • Get the Ori for Me® app (for iOS or for Android). The Ori for Me app offers communication, wellness tips, and life hacks for women living with endometriosis
  • Always ask your gynecologist. He or she knows you the best, and can help find the answers you’re looking for