What is

ORILISSA is specifically made to relieve moderate to severe endometriosis pain

ORILISSA is different—it's not a painkiller, injection, surgery, or birth control. And, it does not contain hormones.

ORILISSA was proven to reduce the 3 most common types of endometriosis pain


Painful periods


Pelvic pain in between periods


Pain with sex*

*Only the 200 mg dose of ORILISSA was proven to work for pain with sex.

ORILISSA starts working quickly

ORILISSA starts working in the body to lower estrogen within 24 hours. However, pain relief will take longer. In clinical studies, ORILISSA was proven to provide pain relief at 3 months.

Less estrogen = less fuel for painful endometriosis lesions

ORILISSA is available in 2 dosing options: 150 mg (taken once a day) or 200 mg (taken twice a day).

Each dose will lower your estrogen by different amounts. Your gynecologist will recommend the dosage that is best for your body and treatment needs.

Estrogen is a hormone that exists naturally in the body.

Want to learn about ORILISSA’s proven results?

125,000 women and counting have been prescribed ORILISSA since 2018.*

*These data reflect the number of women prescribed ORILISSA since FDA approval.
Data were sourced as of March 2023 from IQVIA (Paid Scripts) and Pharmacy Solutions (Bridge Program).

Ready for a change?

Find an OB/GYN who has experience with ORILISSA.


Got questions? We've got answers.

No, ORILISSA is not a painkiller. Painkillers work by either blocking pain messages in the brain or by reducing inflammation (depending on the type of painkiller). ORILISSA was made for endometriosis pain. It works by dialing down estrogen (which is what fuels endometriosis pain).

Also, some painkillers are taken as needed, rather than every day. ORILISSA must be taken every day, even if you’re feeling better. It’s important to take ORILISSA exactly as your doctor prescribed.