Proven Results
of Orilissa

No, ORILISSA is not a painkiller. Painkillers work by either blocking pain messages in the brain or by reducing inflammation (depending on the type of painkiller). ORILISSA was made for endometriosis pain. It works by dialing down estrogen (which is what fuels endometriosis pain).

Also, some painkillers are taken as needed, rather than every day. ORILISSA must be taken every day, even if you’re feeling better. It’s important to take ORILISSA exactly as your doctor prescribed.

ORILISSA was studied in 2 clinical trials; both studies had similar results.

Study 1 results:

ORILISSA was proven to relieve period pain: 46% of women taking ORILISSA 150 mg,^* 76% taking ORILISSA 200 mg,^* and 20% taking placebo^* reported reduced period pain at 3 months.

ORILISSA was also proven to relieve pelvic pain in between periods: 50% of women taking ORILISSA 150 mg,^* 55% taking ORILISSA 200 mg,^* and 36% taking placebo^* reported reduced pelvic pain in between periods at 3 months.

Study 2 results:

ORILISSA was proven to relieve period pain: 43% of women taking ORILISSA 150 mg,^† 72% taking ORILISSA 200 mg,^† and 23% taking placebo^† reported reduced period pain at 3 months.

ORILISSA was also proven to relieve pelvic pain in between periods: 50% of women taking ORILISSA 150 mg,^† 58% taking ORILISSA 200 mg,^† and 37% taking placebo^† reported reduced pelvic pain in between periods at 3 months.

Additionally, the 200 mg dose was proven to relieve pain with sex.^‡

^*Based on 248 women taking ORILISSA 150 mg, 244 women taking ORILISSA 200 mg, and 373 women taking placebo.
^†Based on 221 women taking ORILISSA 150 mg, 225 women taking ORILISSA 200 mg, and 353 women taking placebo.
^‡Only the 200 mg dose was proven to work for pain with sex.

Placebo is a pill with no active medicine—and it’s pretty important when it comes to clinical studies. Because testing against placebo can help assess the difference between taking ORILISSA vs not taking ORILISSA.