Proven Results in Clinical Trials

PROVEN RESULTS IN CLINICAL TRIALS

ORILISSA was proven to reduce 3 common types of endometriosis pain*:

1 Painful periods

2 Pelvic pain in between periods

3 Pain with sex


*There are 2 different doses of ORILISSA: 150 mg (taken once a day) or 200 mg (taken twice a day). Only the 200 mg dose was proven to work for pain with sex.


It was studied in the largest endometriosis clinical trial program to date

The program, made up of two 6-month clinical studies, showed that ORILISSA reduces endometriosis pain. It studied the two doses of ORILISSA (150 mg and 200 mg) against placebo in:

1686 WOMEN

AGES 18-49

With moderate to
severe endo pain


We began measuring women’s pain relief right from the very start

The results below specifically show the measurements we took at 3 months. Both of the studies in the program had similar results. So to get right into it, here are the results from study #1:

1 ORILISSA was proven to relieve period pain

Percent of women who reported reduced period pain at 3 months:


46% of women reported a reduction in period pain at 3 months with ORILISSA 150 mg once a day in clinical trials.
76% of women reported a reduction in period pain at 3 months with ORILISSA 200 mg twice a day in clinical trials.
20% of women reported a reduction in period pain at 3 months with placebo in ORILISSA clinical trials.

These women achieved a reduction in their pain without increasing their use of painkillers.
†Painkillers taken by women in the clinical studies included opioids (hydrocodone with acetaminophen) or naproxen.



2 ORILISSA was proven to relieve pelvic pain in between periods

Percent of women who reported reduced pelvic pain in between periods at 3 months:


50% of women reported a reduction in pelvic pain between periods at 3 months with ORILISSA 150 mg once a day in clinical trials.
55% of women reported a reduction in pelvic pain between periods at month 3 with ORILISSA 200 mg twice a day in clinical trials.
36% of women reported a reduction in pelvic pain between periods at 3 months with placebo in ORILISSA clinical trials.

These women achieved a reduction in their pain without increasing their use of painkillers.§
§Painkillers taken by women in the clinical studies included opioids (hydrocodone with acetaminophen) or naproxen.



3 ORILISSA was proven to relieve pain with sex

¶ Only the 200 mg dose was proven to work for pain with sex.




Do your own research. Don’t let other people dictate what treatment you should or shouldn’t take. Talk to your gynecologist about ORILISSA. See if it works for you.”

Gillian L.


Got questions? We've got answers.

ORILISSA starts working in the body to lower estrogen after about 24 hours. However, pain relief will take longer. In the clinical studies, ORILISSA was proven to provide pain relief at 3 months.

No, ORILISSA is not a painkiller. Painkillers work by either blocking pain messages in the brain or by reducing inflammation (depending on the type of painkiller). ORILISSA was made for endometriosis pain. It works by dialing down estrogen (which is what fuels endometriosis pain).

Also, some painkillers are taken as needed, rather than every day. ORILISSA must be taken every day, even if you’re feeling better. It’s important to take ORILISSA exactly as your doctor prescribed.

Placebo is a pill with no active medicine—and it’s pretty important when it comes to clinical studies. Because testing against placebo can help assess the difference between taking ORILISSA vs not taking ORILISSA.