On this page:
1. Painful periods
2. Pelvic pain in between periods
3. Pain with sex*
*There are 2 different doses of ORILISSA: 150 mg (taken once a day) or 200 mg (taken twice a day). Only the 200 mg dose was proven to work for pain with sex.
Both doses of ORILISSA (150 mg taken once a day or 200 mg taken twice a day) were studied against placebo in two 6-month clinical trials that involved:
These women also did not have an increased use of painkillers† compared to when they began the studies.
In Study 1, more women reported a reduction in pelvic pain in between periods on ORILISSA 150 mg or ORILISSA 200 mg than women on placebo. Similar results were seen in Study 2.
These women also did not have an increased use of painkillers† compared to when they began the studies.
†Painkillers used in the clinical trials were opioids (hydrocodone with acetaminophen) or naproxen.
ORILISSA is not a painkiller. Painkillers work either by blocking pain messages in the brain or by reducing inflammation (depending on the type of painkiller). ORILISSA was made specifically for endometriosis pain. It reduces what fuels endo pain—estrogen.
Also, some painkillers are taken as needed, rather than every day. ORILISSA must be taken every day. It is not a medication you take only as needed. It’s important to take ORILISSA exactly as your doctor prescribed, even if you’re feeling better.
In the ORILISSA clinical trials, researchers compared the effects of ORILISSA against a placebo. This is how researchers could determine whether any benefits or side effects that occurred were caused by ORILISSA.
