HAS COVID-19 MADE PAYING FOR YOUR MEDICINE A CHALLENGE? AbbVie may be able to help. 1-800-ORILISSA (1-800-674-5477)

  • Important Safety Information
  • Full Prescribing Information
  • Medication Guide for Patients
  • Healthcare Professional Website
  • +
    • Important Safety Information
    • Full Prescribing Information
    • Medication Guide for Patients
    • Healthcare Professional Website
    • Pregnancy Registry
    • Cost & Savings
  • Pregnancy Registry
  • Cost & Savings
ORILISSA® (elagolix) 150 mg and 200 mg
GET A SAVINGS CARD
  • HOME
  • ABOUT ORILISSA
    • What is ORILISSA?
    • How ORILISSA Works
    • ORILISSA Stories and Reviews
    • Proven Results of ORILISSA
    • Understanding Side Effects
    • Taking ORILISSA
  • READY FOR A CHANGE
    • Talk to Your OB/GYN
    • Find an OB/GYN
  • ORILISSA SAVINGS
  • WHAT IS ENDOMETRIOSIS
  • GET A SAVINGS CARD

Site Map

Home

About ORILISSA

  • What is ORILISSA?
  • How ORILISSA Works
  • ORILISSA Stories and Reviews
  • Proven Results of ORILISSA
  • Understanding Side Effects
  • Taking ORILISSA

Ready for a Change

  • Talk to Your OB/GYN
  • Find an OB/GYN

ORILISSA Savings

What is Endometriosis?

USE

ORILISSA® (elagolix) is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if ORILISSA is safe and effective in children.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ORILISSA?

ORILISSA may cause serious side effects, including bone loss and effects on pregnancy:

  • Bone Loss (decreased Bone Mineral Density [BMD])
    While you are taking ORILISSA, your estrogen levels will be low. This can lead to BMD loss. If you have bone loss on ORILISSA, your BMD may improve after stopping ORILISSA, but may not recover completely. It is unknown if these bone changes could increase your risk for broken bones as you age. For this reason, your healthcare provider (HCP) may limit the length of time you take ORILISSA. Your HCP may order a DXA scan to check your BMD.
  • Effects on Pregnancy
    Do not take 
    ORILISSA if you are trying to become or are pregnant, as your risk for early pregnancy loss may increase. If you think you are pregnant, stop taking ORILISSA right away and call your HCP. ORILISSA may change your menstrual periods (irregular bleeding or spotting, a decrease in menstrual bleeding, or no bleeding at all), making it hard to know if you are pregnant. Watch for other signs of pregnancy, such as breast tenderness, weight gain, and nausea. ORILISSA does not prevent pregnancy. You will need to use effective hormone-free birth control (such as condoms or spermicide) while taking ORILISSA and for 28 days after stopping ORILISSA. Birth control pills that contain estrogen may make ORILISSA less effective. It is unknown how well ORILISSA works while on progestin-only birth control.

Do not take ORILISSA if you:

  • Are pregnant, have osteoporosis, have severe liver disease, are taking medicines called organic anion transporting polypeptide (OATP) 1B1 inhibitors that are known or expected to significantly increase the blood levels of elagolix, the active ingredient in ORILISSA (ask your HCP if you are not sure if you are taking one of these medicines), or have had a serious allergic reaction to ORILISSA or any of the ingredients in ORILISSA. See the end of the Medication Guide for a complete list of ingredients in ORILISSA. Ask your HCP if you are not sure.

What should I tell my HCP before taking ORILISSA?

Tell your HCP about all of your medical conditions, including if you:

  • Have or have had broken bones or other conditions that may cause bone problems; have or have had depression, mood problems, or suicidal thoughts or behavior; have liver problems; think you may be pregnant; or are breastfeeding or plan to be. It is unknown if ORILISSA passes into breast milk. Talk to your HCP about the best way to feed your baby if you take ORILISSA.

Tell your HCP about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your HCP if you take birth control that contains hormones. Your HCP may advise you to change your method of birth control.

What are the possible side effects of ORILISSA?

ORILISSA can cause serious side effects including:

  • Suicidal thoughts, actions, or behavior, and worsening of mood. Call your HCP or get emergency medical help right away if you have any of these symptoms, especially if they are new, worse, or bother you: thoughts about suicide or dying, attempts to commit suicide, new or worse depression or anxiety, or other unusual changes in behavior or mood. You or your caregiver should pay attention to any changes, especially sudden changes in your mood, behaviors, thoughts, or feelings.
  • Abnormal liver tests. Call your HCP right away if you have any of these signs and symptoms of liver problems: yellowing of the skin or the whites of the eyes (jaundice), dark amber-colored urine, feeling tired, nausea and vomiting, generalized swelling, right upper stomach area pain, or bruising easily.

The most common side effects of ORILISSA include: hot flashes and night sweats, headache, nausea, difficulty sleeping, absence of periods, anxiety, joint pain, depression, and mood changes.

These are not all of the possible side effects of ORILISSA. This is the most important information to know about ORILISSA. For more information, talk to your HCP.

Take ORILISSA exactly as your HCP tells you. Tell your HCP if you have any side effect that bothers you or that does not go away. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.


US-ORIL-210096

Please click here for Full Prescribing Information and Medication Guide.

 

  • Home
  • Site Map
  • Contact Us
  • Privacy Policy
  • Terms of Use
  • Advertising Choices
  • Cookies Settings

Legal Notices/Privacy Policy. Copyright 2022, AbbVie Inc., North Chicago, Illinois, U.S.A. If you have any questions about AbbVie’s ORILISSA.com website that have not been answered, click here. This website and the information contained herein is intended for use by US residents only, is provided for informational purposes only and is not intended to replace a discussion with a healthcare provider. All decisions regarding patients must be made with a healthcare provider and consider the unique characteristics of each patient.

© 2022 AbbVie. All rights reserved.

US-ORIL-220072

So long for now...

By clicking this link, you will be leaving this site and connecting to a site neither owned nor operated by AbbVie. AbbVie is not responsible for the contents of any such website or any further links from such website. AbbVie is providing these links as a convenience, and the inclusion of any link does not imply endorsement of the linked website by AbbVie. You should also be aware that the linked website may be governed by its own set of terms and conditions and privacy policy, for which AbbVie has no responsibility.

Cancel
Continue

US-ORIL-210343

So long for now...

By clicking this link, you will be leaving this site and connecting to a site neither owned nor operated by AbbVie. AbbVie is not responsible for the contents of any such website or any further links from such website. AbbVie is providing these links as a convenience, and the inclusion of any link does not imply endorsement of the linked website by AbbVie. You should also be aware that the linked website may be governed by its own set of terms and conditions and privacy policy, for which AbbVie has no responsibility.

Back
Continue

US-ORIL-200445

You are about to enter a site that is for U.S. Healthcare Professionals Only.

By selecting "Continue" below, you certify that you are a Healthcare Professional. Products or treatments described on this site are available in the U.S. but may not be available in all other countries. I am a licensed Healthcare Professional and wish to proceed to the Healthcare Professionals Only section of this site.

Back
Continue

US-ORIL-200445

Share

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

US-ORIL-200445

Share

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

US-ORIL-200046

Share

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

US-ORIL-200046

So long for now...

By clicking this link, you will be leaving this site and connecting to a site neither owned nor operated by AbbVie. AbbVie is not responsible for the contents of any such website or any further links from such website. AbbVie is providing these links as a convenience, and the inclusion of any link does not imply endorsement of the linked website by AbbVie. You should also be aware that the linked website may be governed by its own set of terms and conditions and privacy policy, for which AbbVie has no responsibility.

Cancel
Continue

US-ORIL-200445

So long for now...

By clicking this link, you will be leaving this site and connecting to a site neither owned nor operated by AbbVie. AbbVie is not responsible for the contents of any such website or any further links from such website. AbbVie is providing these links as a convenience, and the inclusion of any link does not imply endorsement of the linked website by AbbVie. You should also be aware that the linked website may be governed by its own set of terms and conditions and privacy policy, for which AbbVie has no responsibility.

Cancel
Continue

US-ORIL-200046

So long for now...

By clicking this link, you will be leaving this site and connecting to a site neither owned nor operated by AbbVie. AbbVie is not responsible for the contents of any such website or any further links from such website. AbbVie is providing these links as a convenience, and the inclusion of any link does not imply endorsement of the linked website by AbbVie. You should also be aware that the linked website may be governed by its own set of terms and conditions and privacy policy, for which AbbVie has no responsibility.

Cancel
Continue

US-ORIL-200046

Pregnancy Registry Information

AbbVie serves as the sponsor of a study, which monitors the pregnancy outcomes of women exposed to ORILISSA® (elagolix) while pregnant. To conduct this study, AbbVie contracted with a third-party Contract Research Organization.

By clicking “Proceed” below, you will be redirected to a third-party website maintained by the Contract Research Organization. Data collected on that website may assist the Contract Research Organization in the conduct of the study. AbbVie will not receive, or have access to, identifiable data shared through use of that website.

If you become pregnant while taking ORILISSA, you are encouraged to enroll in the Pregnancy Registry. The purpose of the pregnancy registry is to collect information about the health of you and your baby. Talk to your healthcare provider or call 1-833-782-7241 or visit www.bloompregnancyregistry.com to enroll.

DO NOT take ORILISSA if you are pregnant or trying to become pregnant. It may increase the risk of early pregnancy loss. If you think you are pregnant, stop taking ORILISSA right away and call your healthcare provider.

Close
Proceed

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ORILISSA?

ORILISSA may cause serious side effects, including bone loss and effects on pregnancy:

USE

ORILISSA® (elagolix) is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is

USE

ORILISSA® (elagolix) is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if ORILISSA is...

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ORILISSA?

ORILISSA may cause serious side effects, including bone loss and effects on pregnancy:

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ORILISSA?

ORILISSA may cause serious side effects, including bone loss and effects on pregnancy:

USE

ORILISSA® (elagolix) is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is

USE

ORILISSA® (elagolix) is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if ORILISSA is...

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ORILISSA?

ORILISSA may cause serious side effects, including bone loss and effects on pregnancy:

USE

ORILISSA® (elagolix) is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if ORILISSA is safe and effective in children.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ORILISSA?

ORILISSA may cause serious side effects, including bone loss and effects on pregnancy:

  • Bone Loss (decreased Bone Mineral Density [BMD])
    While you are taking ORILISSA, your estrogen levels will be low. This can lead to BMD loss. If you have bone loss on ORILISSA, your BMD may improve after stopping ORILISSA, but may not recover completely. It is unknown if these bone changes could increase your risk for broken bones as you age. For this reason, your healthcare provider (HCP) may limit the length of time you take ORILISSA. Your HCP may order a DXA scan to check your BMD.
  • Effects on Pregnancy
    Do not take 
    ORILISSA if you are trying to become or are pregnant, as your risk for early pregnancy loss may increase. If you think you are pregnant, stop taking ORILISSA right away and call your HCP. ORILISSA may change your menstrual periods (irregular bleeding or spotting, a decrease in menstrual bleeding, or no bleeding at all), making it hard to know if you are pregnant. Watch for other signs of pregnancy, such as breast tenderness, weight gain, and nausea. ORILISSA does not prevent pregnancy. You will need to use effective hormone-free birth control (such as condoms or spermicide) while taking ORILISSA and for 28 days after stopping ORILISSA. Birth control pills that contain estrogen may make ORILISSA less effective. It is unknown how well ORILISSA works while on progestin-only birth control.

Do not take ORILISSA if you:

  • Are pregnant, have osteoporosis, have severe liver disease, are taking medicines called organic anion transporting polypeptide (OATP) 1B1 inhibitors that are known or expected to significantly increase the blood levels of elagolix, the active ingredient in ORILISSA (ask your HCP if you are not sure if you are taking one of these medicines), or have had a serious allergic reaction to ORILISSA or any of the ingredients in ORILISSA. See the end of the Medication Guide for a complete list of ingredients in ORILISSA. Ask your HCP if you are not sure.

What should I tell my HCP before taking ORILISSA?

Tell your HCP about all of your medical conditions, including if you:

  • Have or have had broken bones or other conditions that may cause bone problems; have or have had depression, mood problems, or suicidal thoughts or behavior; have liver problems; think you may be pregnant; or are breastfeeding or plan to be. It is unknown if ORILISSA passes into breast milk. Talk to your HCP about the best way to feed your baby if you take ORILISSA.

Tell your HCP about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your HCP if you take birth control that contains hormones. Your HCP may advise you to change your method of birth control.

What are the possible side effects of ORILISSA?

ORILISSA can cause serious side effects including:

  • Suicidal thoughts, actions, or behavior, and worsening of mood. Call your HCP or get emergency medical help right away if you have any of these symptoms, especially if they are new, worse, or bother you: thoughts about suicide or dying, attempts to commit suicide, new or worse depression or anxiety, or other unusual changes in behavior or mood. You or your caregiver should pay attention to any changes, especially sudden changes in your mood, behaviors, thoughts, or feelings.
  • Abnormal liver tests. Call your HCP right away if you have any of these signs and symptoms of liver problems: yellowing of the skin or the whites of the eyes (jaundice), dark amber-colored urine, feeling tired, nausea and vomiting, generalized swelling, right upper stomach area pain, or bruising easily.

The most common side effects of ORILISSA include: hot flashes and night sweats, headache, nausea, difficulty sleeping, absence of periods, anxiety, joint pain, depression, and mood changes.

These are not all of the possible side effects of ORILISSA. This is the most important information to know about ORILISSA. For more information, talk to your HCP.

Take ORILISSA exactly as your HCP tells you. Tell your HCP if you have any side effect that bothers you or that does not go away. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.


US-ORIL-210096