How ORILISSA works


Women are sharing their experiences with ORILISSA

These women sat down to get real about their struggles with endometriosis…and why they chose to try ORILISSA for their moderate to severe endo pain.

Explore the categories below to hear how ORILISSA became a part of their treatment journeys.


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Three women discuss life with endometriosis pain

Listen in as these three women share their personal struggles with endometriosis, and how taking ORILISSA helped them discover endo pain relief.

What motivated Darby to try ORILISSA

“A lot of my daily routine depended on and revolved around my endometriosis pain.” Click to watch this video about Darby’s treatment decision.

Amy's glad she and her GYN chose ORILISSA

Amy weighed the risks and potential side effects of ORILISSA with her GYN. Find out why ORILISSA was the right choice for her.

Sarah’s grateful for her Ori for Me® Nurse

Starting a medication can bring up a lot of questions. Check out the video to find out how Nurse Judy supports patients like Sarah.

Get to know more women who have taken ORILISSA

All these women have their own endometriosis journeys that led them to try ORILISSA for their moderate to severe endo pain. Click their profile to learn more about them.

I’ve struggled with debilitating pelvic pain since I was 11 years old. When I was 18, the pain was so bad that I passed out. I was rushed to the emergency room and that’s when I was diagnosed with endometriosis. I was relieved to find out there was a reason for my pain, but the gynecologist’s vague description of how to manage my painful symptoms left me confused.

I saw so many gynecologists who all recommended various kinds of birth control and over-the-counter pain medications. But nothing seemed to help my endometriosis pain. I didn’t know what to do and I didn’t know who to turn to. Luckily my mom saw that I was struggling and suggested we see a new gynecologist who was recommended to her. Her office was kind of far from where we lived, but we decided it was worth it, even if we had to travel a bit for the appointment.

This gynecologist took my endometriosis pain seriously and suggested I try ORILISSA. I had never heard of it, so I went home and did a lot of research and saw that over a thousand women were in the clinical trials. At my next appointment, we talked more and decided it was something I should try. I’m glad I did—with ORILISSA, my endometriosis pain’s gone down. And that’s something I want to share with others.

After dealing with severe pelvic pain for as long as I can remember, I was finally diagnosed with endometriosis at 38. I spent the next few years putting on a smile and pushing through my pain. I’m a kindergarten teacher’s assistant, so it’s my job to inspire a love of learning in my students from an early age. But it was challenging for me to bring that excitement to the classroom each day while struggling with debilitating pelvic pain.

I didn’t know what to do. I’d tried treatment options that worked for others, but they didn’t work for me. And, surgery wasn’t an option for me either. So I felt stuck. That’s when I scheduled another appointment with my gynecologist. She told me about an option that might help my endometriosis pain—ORILISSA.

We talked all about it and weighed the benefits against the potential side effects. Together, we decided that I should try it. And I’m so glad I did. Since taking ORILISSA, I have less endometriosis pain. I hope by sharing my story, I can encourage other women to speak up and talk to their gynecologists about their options.

For 10 years, I suffered through painful periods and pelvic pain—it felt like someone was constantly pinching and pulling my uterus. After an emergency surgery, I was diagnosed with endometriosis. For the next several years, I was prescribed birth control to manage my endometriosis pain, but the pain persisted.

Over time, my pelvic pain got worse and I became more frustrated. Nothing seemed to work and I felt like I was running out of options. That’s when my gynecologist suggested ORILISSA. I was interested, so I decided to do my own research and see what I could find.

After posting on social media about it, I heard many different opinions, and some were not so great. Some of the responses even made me feel bullied. So, I went back to my gynecologist to ask about what I was reading online. He explained everything I needed to know about ORILISSA, including the benefits and the risks. And after a long discussion, I decided it was the right option for me to try.

I’m so happy I decided to try it because it reduced my endometriosis pain. I want to share my experience on ORILISSA, encourage other women to do their own research, and speak with their gynecologist, instead of just listening to what people say on social media.

I began experiencing painful periods at 12 years old. At age 16, I was put on birth control and took over-the-counter painkillers for my “bad periods.” Two years later, I stumbled upon an article about endometriosis—it made me wonder if what I had was more than just cramps. My suspicions were confirmed when I was officially diagnosed with endometriosis at 21.

After that, I tried different types of birth control and injections. Although they work for some women, none of these treatments worked for my endometriosis pain.

Then, my gynecologist told me about ORILISSA. We talked about it and it sounded like the right option for me.

3 months after taking ORILISSA, I was out shopping with my mom when suddenly I realized—my pain wasn’t hurting like it used to. I didn’t have to stop and take breaks for my pain to subside. That was the moment I knew ORILISSA worked for me. With ORILISSA, I felt endometriosis pain relief. The cramping feeling lessened and my everyday pain decreased.

I’m passionate about sharing my ORILISSA experience and I want to encourage others to talk to their gynecologists to see if it could be right for them.

I remember my first period at 11 years old being painful. Over the next 5 years, that pain only got worse. My doctor prescribed birth control to see if that would help, but it didn’t. By age 21, my pelvic pain became so debilitating that there were days I struggled to get out of bed. I went back to my doctor in hope of answers.

Eventually, I was referred to a new gynecologist who diagnosed me with endometriosis. I felt so relieved. People had told me that my pain was in my head, but now I finally had a diagnosis that proved it was real.

Following my diagnosis, my gynecologist and I tried many treatment options to relieve my endometriosis pain. But sometimes it still affected me when it came to making plans or going to work. It was frustrating. So I went back to my gynecologist and told him I needed another option. That’s when he recommended ORILISSA.

Since taking ORILISSA, my endometriosis pain has decreased. I’m excited to share my ORILISSA story and hope that other women who are suffering will talk to their gynecologists about this treatment option.

My pelvic pain began as a teenager. My mother and grandmother had similar symptoms and were both diagnosed with endometriosis, which left me wondering if my pelvic pain could be caused by endometriosis, too.

For 10 years, I simply dealt with the constant pain—both during my period and throughout the month—but then, I hit a breaking point. I was working my dream job, but I was having trouble hiding my pain at work. I decided I needed to do something.

I changed physicians and finally found a gynecologist who I trusted. We had a conversation about my medical history and he did an exam and clinically diagnosed me with endometriosis. Immediately he told me about ORILISSA, and I decided to give it a try.

With ORILISSA, my periods have been less painful. I hope women talk to their gynecologists to see if ORILISSA could be right for their endometriosis pain. For me—ORILISSA was the right choice.

I was diagnosed with endometriosis at 22, after dealing with severe pelvic pain for 6 years. I tried various forms of birth control and had 2 surgeries—neither did much to help my pain.

I was so fed up that, at only 34 years old, I asked my gynecologist if I should have a hysterectomy. That’s when he told me about a totally different option—a pill called ORILISSA!

On ORILISSA, I have less pain. This lets me get back to things I love, like working out and playing softball. I hope my experience empowers other women and gives them hope that there are other options out there.

I’m 38 years old and was diagnosed with endometriosis at 28. For 15 years I suffered through painful periods, pain with sex, and severe pelvic pain. My doctor tried to treat it with birth control, injections, and a partial hysterectomy.

I used all of my energy just to get through the workday and didn’t feel up to doing much else once I got home. I felt so guilty when I couldn’t spend the time I wanted with my kids because of constant pain and exhaustion—but then I discovered ORILISSA. It has really helped with my pain—so I can get back to spending more time with my sons.

It’s important for women with endometriosis like me to feel like they can speak up. I hope my story can help others find their voice and a treatment that works for them.

I’m 39 years old and was diagnosed with endometriosis at 25, after struggling for 12 years. I experienced pelvic pain and cramps and tried to treat it with various forms of birth control (pills, IUD, and injections) and various prescription painkillers.

The pain affected so many aspects of my life, but especially the time I spent with my friends and family. I couldn’t fully enjoy family outings, and I kept having to cancel on my friends.

With ORILISSA, I was in less endo pain. Being in less pain allowed me to get back to doing some of the things I love—like cooking and spending more time with my daughters. I hope sharing my story will help other women learn about ORILISSA and encourage them to be more outspoken about their endo pain and need for treatment options.

My name's Kat and I was diagnosed with endometriosis when I was 28. A year before that, I noticed a change when my periods became really painful and I even started having pelvic pain in between my periods. There were times when it felt like a cheese grater was just scraping me raw.

I mentioned it to my gynecologist, but I wasn’t ready to do anything about it. The pain would come and go and I just sort of hoped it would go away. But it didn’t…it only got worse. Finally, I realized I couldn’t just manage it on my own. So, I made a new appointment with my gynecologist. And this time, I was ready to prioritize my pain and get to the bottom of it.

Before the appointment, I took the time to make a list of all my symptoms—even the little things that didn’t seem like they’d matter—and brought it with me. It actually helped start the conversation. And it helped my gynecologist understand my situation better than if I had just tried to explain things on my own.

After discussing the list, she gave me a pelvic exam and diagnosed me with endometriosis that day. Then we talked about treatments for my endometriosis pain. One option was surgery, which I know is right for some women, but I really didn’t want it. But there was another option she recommended—a pill called ORILISSA—that I was excited to learn about. We decided to give it a try and I’m glad we did because on ORILISSA, I have less pain.

At first, I wasn’t sure if making that list of symptoms would help. But it turns out, it’s what got the ball rolling and led to my diagnosis and ORILISSA. That’s why I volunteered to tell my story. To let you know that whether you’ve got a new gynecologist or one you’ve known for years, sharing every detail, even ones that feel unimportant, can help get answers. If you’re not sure where to start, make a list. It may not seem like a big deal, but it can make a big difference.

When I was 22, I was diagnosed with endometriosis. I was relieved to get a diagnosis, but I still had questions…What now? How could I manage my endometriosis pain? Was it just something I would always have to deal with? It’s not like getting diagnosed suddenly made the pain go away. It was still there, always lurking.

For instance, my husband and I love riding motorcycles together. The open road would usually take my mind off things. But now, the bike just made my endometriosis pain worse—all the twists and turns were unbearable. And it was tough for me to enjoy our trips together. All I could think about was my pelvic pain.

I also had pain with sex, which was awful—it turned sex into something I dreaded. And I felt like, when we did have sex, I just couldn’t stay present. At first, I tried to hide the pain, but the longer we were married, I couldn't fake how I felt.

So, for about 13 years, I tried managing my symptoms with birth control and surgery, but it didn’t really help my endometriosis pain. Finally, I reached my breaking point and decided to go back to my gynecologist to talk about trying something else. That’s when he suggested I try ORILISSA—he told me that it’s the only pill that's clinically proven to relieve moderate to severe endometriosis pain. It was so exciting! It gave me hope for, not just me, but other women with endo pain, too.

I'm so grateful that my gynecologist suggested ORILISSA because it worked for me—it reduced the pain I had with sex, the pain during my periods, and the pain in between my periods, too. And that’s why I’m sharing my story here. Maybe it can help other women speak up and find an option that works for them.

ORILISSA—Proven to relieve endometriosis pain

Discover the benefits of ORILISSA, proven in the largest endometriosis clinical trial program to date.

As of October 2019 over 35,000 women have been prescribed ORILISSA.