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    Orilissa® Complete Access Specialists are a resource with expertise regarding potential options to consider based on each patient's unique insurance coverage situation.

    For support, call

    >90 % * of insured patients nationwide have access to ORILISSA2

    *As of July 15, 2020.
    Coverage varies by channel: Commercial: 94%;
    Managed Medicaid: 76%; Fee-for-Service Medicaid: 79%;
    Department of Defense/Veterans Affairs: 100%.

    Coverage requirements and benefit designs vary by payer and may change over time. Please consult with payers directly for the most current reimbursement policies. The health plans and/or pharmacy benefit managers listed here have not endorsed and are not affiliated with this material.

    Benefits verification

    Orilissa Complete includes access to Insurance Specialists who can help your patients understand their insurance coverage. Find out more by calling Orilissa Complete at 1-800-ORILISSA (1-800-674-5477) or by filling out the Orilissa Complete Enrollment & Prescription Form and faxing it to 1-833-674-5477.

    Formulary definitions: Access means the product is covered and not NDC blocked. Restrictions may apply. Available and/or Covered is defined as patient has access and plan coverage of product at any formulary or non-formulary tier and product is not NDC blocked. Step edits, prior authorization, and other restrictions apply. Covered on formulary is defined as patient has access and plan coverage of product at any formulary tier and product is not NDC blocked. Step edits, prior authorization, and other restrictions apply. Lowest Branded Copay means the product is in the formulary tier status designated by the insurer as the lowest branded copay in the therapeutic class.

    Indication and Important Safety Information

    INDICATION1

    ORILISSA® (elagolix) is indicated for the management of moderate to severe pain associated with endometriosis.

    IMPORTANT SAFETY INFORMATION1

    CONTRAINDICATIONS

    • ORILISSA is contraindicated in women who are pregnant (exposure to ORILISSA early in pregnancy may increase the risk of early pregnancy loss), in women with known osteoporosis or severe hepatic impairment, or with concomitant use of strong organic anion transporting polypeptide (OATP) 1B1 inhibitors (e.g., cyclosporine and gemfibrozil).

    WARNINGS AND PRECAUTIONS

    Bone Loss

    • ORILISSA causes a dose-dependent decrease in bone mineral density (BMD), which is greater with increasing duration of use and may not be completely reversible after stopping treatment.
    • The impact of ORILISSA-associated decreases in BMD on long-term bone health and future fracture risk is unknown. Consider assessment of BMD in patients with a history of low-trauma fracture or other risk factors for osteoporosis or bone loss, and do not use in women with known osteoporosis.
    • Limit the duration of use to reduce the extent of bone loss.

    Change in Menstrual Bleeding Pattern and Reduced Ability to Recognize Pregnancy

    • Women who take ORILISSA may experience a reduction in the amount, intensity, or duration of menstrual bleeding, which may reduce the ability to recognize the occurrence of pregnancy in a timely manner. Perform pregnancy testing if pregnancy is suspected, and discontinue ORILISSA if pregnancy is confirmed.

    Suicidal Ideation, Suicidal Behavior, and Exacerbation of Mood Disorders

    • Suicidal ideation and behavior, including one completed suicide, occurred in subjects treated with ORILISSA in the endometriosis clinical trials.
    • ORILISSA users had a higher incidence of depression and mood changes compared to placebo and ORILISSA users with a history of suicidality or depression had an increased incidence of depression. Promptly evaluate patients with depressive symptoms to determine whether the risks of continued therapy outweigh the benefits. Patients with new or worsening depression, anxiety, or other mood changes should be referred to a mental health professional, as appropriate.
    • Advise patients to seek immediate medical attention for suicidal ideation and behavior. Reevaluate the benefits and risks of continuing ORILISSA if such events occur.

    Hepatic Transaminase Elevations

    • In clinical trials, dose-dependent elevations of serum alanine aminotransferase (ALT) at least 3 times the upper limit of the reference range occurred with ORILISSA.
    • Use the lowest effective dose and instruct patients to promptly seek medical attention in case of symptoms or signs that may reflect liver injury, such as jaundice.
    • Promptly evaluate patients with elevations in liver tests to determine whether the benefits of continued therapy outweigh the risks.

    Reduced Efficacy with Estrogen-Containing Contraceptives

    • Based on the mechanism of action of ORILISSA, estrogen-containing contraceptives are expected to reduce the efficacy of ORILISSA. The effect of progestin-only contraceptives on the efficacy of ORILISSA is unknown.
    • Advise women to use non-hormonal contraceptives during treatment and for one week after discontinuing ORILISSA.

    ADVERSE REACTIONS

    • The most common adverse reactions (>5%) in clinical trials included hot flushes and night sweats, headache, nausea, insomnia, amenorrhea, anxiety, arthralgia, depression-related adverse reactions, and mood changes.

    These are not all the possible side effects of ORILISSA.

    Safety and effectiveness of ORILISSA in patients less than 18 years of age have not been established.

    US-ORIL-200330

    For more information, please click here for full Prescribing Information.

    References:

    1. ORILISSA [package insert]. North Chicago, IL: AbbVie Inc. 2. Data on file. AbbVie Inc. Payer reported lives. July 2020.

    Indication and Important Safety Information

    INDICATION1

    ORILISSA® (elagolix) is indicated for the management of moderate to severe pain associated with endometriosis. Limit the duration of use based on the dose and coexisting condition.

    IMPORTANT SAFETY INFORMATION1

    CONTRAINDICATIONS

    • ORILISSA is contraindicated in women who are pregnant (exposure to ORILISSA early in pregnancy may increase the risk of early pregnancy loss), in women with known osteoporosis or severe hepatic impairment, in women taking organic anion transporting polypeptide (OATP) 1B1 inhibitors that are known or expected to significantly increase elagolix plasma concentrations, and in women with known hypersensitivity reaction to ORILISSA or any of its inactive components. Reactions have included anaphylaxis and angioedema.

    WARNINGS AND PRECAUTIONS

    Bone Loss

    • ORILISSA causes a dose-dependent decrease in bone mineral density (BMD), which is greater with increasing duration of use and may not be completely reversible after stopping treatment.
    • The impact of ORILISSA-associated decreases in BMD on long-term bone health and future fracture risk is unknown. ORILISSA is contraindicated in women with known osteoporosis. Consider assessment of BMD in patients with a history of low-trauma fracture or other risk factors for osteoporosis or bone loss.
    • Limit the duration of use to reduce the extent of bone loss.

    Change in Menstrual Bleeding Pattern and Reduced Ability to Recognize Pregnancy

    • Women who take ORILISSA may experience a reduction in the amount, intensity, or duration of menstrual bleeding, which may reduce the ability to recognize the occurrence of pregnancy in a timely manner. Perform pregnancy testing if pregnancy is suspected, and discontinue ORILISSA if pregnancy is confirmed.

    Suicidal Ideation, Suicidal Behavior, and Exacerbation of Mood Disorders

    • Suicidal ideation and behavior, including one completed suicide, occurred in subjects treated with ORILISSA in the endometriosis clinical trials.
    • ORILISSA users had a higher incidence of depression and mood changes compared to placebo and ORILISSA users with a history of suicidality or depression had an increased incidence of depression. Promptly evaluate patients with depressive symptoms to determine whether the risks of continued therapy outweigh the benefits. Patients with new or worsening depression, anxiety, or other mood changes should be referred to a mental health professional, as appropriate.
    • Advise patients to seek immediate medical attention for suicidal ideation and behavior. Reevaluate the benefits and risks of continuing ORILISSA if such events occur.

    Hepatic Transaminase Elevations

    • In clinical trials, dose-dependent elevations of serum alanine aminotransferase (ALT) at least 3 times the upper limit of the reference range occurred with ORILISSA.
    • Use the lowest effective dose and instruct patients to promptly seek medical attention in case of symptoms or signs that may reflect liver injury, such as jaundice.
    • Promptly evaluate patients with elevations in liver tests to determine whether the benefits of continued therapy outweigh the risks.

    Interactions with Hormonal Contraceptives

    • Advise women to use effective non-hormonal contraceptives during treatment and for 28 days after discontinuing ORILISSA.
    • Coadministration of ORILISSA 200 mg twice daily with an estrogen-containing contraceptive is not recommended because of the potential for increased estrogen-associated risks including thromboembolic disorders and vascular events. Coadministration of ORILISSA with an estrogen-containing contraceptive is expected to reduce the efficacy of ORILISSA.
    • Coadministration with progestin-containing oral contraceptives may reduce the efficacy of the contraceptive. The effect of progestin-only contraceptives on the efficacy of ORILISSA is unknown. Coadministration of ORILISSA with progestin-containing intrauterine contraceptive systems has not been studied.

    ADVERSE REACTIONS

    • The most common adverse reactions (>5%) in clinical trials included hot flushes and night sweats, headache, nausea, insomnia, amenorrhea, anxiety, arthralgia, depression-related adverse reactions, and mood changes.

    These are not all the possible side effects of ORILISSA.

    Safety and effectiveness of ORILISSA in pediatric patients have not been established.

    US-ORIL-210045

    For more information, please click here for full Prescribing Information.

    References:

    1. ORILISSA [package insert]. North Chicago, IL: AbbVie Inc. 2. Data on file. AbbVie Inc. Payer reported lives. July 2020.

    IMPORTANT SAFETY INFORMATION1

    CONTRAINDICATIONS

    ORILISSA is contraindicated in women who are pregnant (exposure to ORILISSA early in pregnancy may increase the risk of early pregnancy loss), in women with known...

    INDICATION1

    ORILISSA® (elagolix) is indicated for the management of moderate to severe pain associated with endometriosis. Limit the duration of use based on the dose and coexisting condition.

    IMPORTANT SAFETY INFORMATION1

    CONTRAINDICATIONS

    ORILISSA is contraindicated in women who are pregnant (exposure to ORILISSA early in pregnancy may increase the risk of early pregnancy loss), in women with osteoporosis or severe hepatic impairment...

    INDICATION1

    ORILISSA® (elagolix) is indicated for the management of moderate to severe pain associated with endometriosis. Limit the duration of use based on the dose and coexisting condition.

    IMPORTANT SAFETY INFORMATION1

    CONTRAINDICATIONS

    ORILISSA is contraindicated in women who are pregnant (exposure to ORILISSA early in pregnancy may increase the risk of early pregnancy loss), in women with known...

    INDICATION1

    ORILISSA® (elagolix) is indicated for the management of moderate to severe pain associated with endometriosis. Limit the duration of use based on the dose and coexisting condition.

    IMPORTANT SAFETY INFORMATION1

    CONTRAINDICATIONS

    ORILISSA is contraindicated in women who are pregnant (exposure to ORILISSA early in pregnancy may increase the risk of early pregnancy loss), in women with osteoporosis or severe hepatic impairment...

    INDICATION1

    ORILISSA® (elagolix) is indicated for the management of moderate to severe pain associated with endometriosis. Limit the duration of use based on the dose and coexisting condition.

    Indication and Important Safety Information

    INDICATION1

    ORILISSA® (elagolix) is indicated for the management of moderate to severe pain associated with endometriosis. Limit the duration of use based on the dose and coexisting condition.

    IMPORTANT SAFETY INFORMATION1

    CONTRAINDICATIONS

    • ORILISSA is contraindicated in women who are pregnant (exposure to ORILISSA early in pregnancy may increase the risk of early pregnancy loss), in women with known osteoporosis or severe hepatic impairment, in women taking organic anion transporting polypeptide (OATP) 1B1 inhibitors that are known or expected to significantly increase elagolix plasma concentrations, and in women with known hypersensitivity reaction to ORILISSA or any of its inactive components. Reactions have included anaphylaxis and angioedema.

    WARNINGS AND PRECAUTIONS

    Bone Loss

    • ORILISSA causes a dose-dependent decrease in bone mineral density (BMD), which is greater with increasing duration of use and may not be completely reversible after stopping treatment.
    • The impact of ORILISSA-associated decreases in BMD on long-term bone health and future fracture risk is unknown. ORILISSA is contraindicated in women with known osteoporosis. Consider assessment of BMD in patients with a history of low-trauma fracture or other risk factors for osteoporosis or bone loss.
    • Limit the duration of use to reduce the extent of bone loss.

    Change in Menstrual Bleeding Pattern and Reduced Ability to Recognize Pregnancy

    • Women who take ORILISSA may experience a reduction in the amount, intensity, or duration of menstrual bleeding, which may reduce the ability to recognize the occurrence of pregnancy in a timely manner. Perform pregnancy testing if pregnancy is suspected, and discontinue ORILISSA if pregnancy is confirmed.

    Suicidal Ideation, Suicidal Behavior, and Exacerbation of Mood Disorders

    • Suicidal ideation and behavior, including one completed suicide, occurred in subjects treated with ORILISSA in the endometriosis clinical trials.
    • ORILISSA users had a higher incidence of depression and mood changes compared to placebo and ORILISSA users with a history of suicidality or depression had an increased incidence of depression. Promptly evaluate patients with depressive symptoms to determine whether the risks of continued therapy outweigh the benefits. Patients with new or worsening depression, anxiety, or other mood changes should be referred to a mental health professional, as appropriate.
    • Advise patients to seek immediate medical attention for suicidal ideation and behavior. Reevaluate the benefits and risks of continuing ORILISSA if such events occur.

    Hepatic Transaminase Elevations

    • In clinical trials, dose-dependent elevations of serum alanine aminotransferase (ALT) at least 3 times the upper limit of the reference range occurred with ORILISSA.
    • Use the lowest effective dose and instruct patients to promptly seek medical attention in case of symptoms or signs that may reflect liver injury, such as jaundice.
    • Promptly evaluate patients with elevations in liver tests to determine whether the benefits of continued therapy outweigh the risks.

    Interactions with Hormonal Contraceptives

    • Advise women to use effective non-hormonal contraceptives during treatment and for 28 days after discontinuing ORILISSA.
    • Coadministration of ORILISSA 200 mg twice daily with an estrogen-containing contraceptive is not recommended because of the potential for increased estrogen-associated risks including thromboembolic disorders and vascular events. Coadministration of ORILISSA with an estrogen-containing contraceptive is expected to reduce the efficacy of ORILISSA.
    • Coadministration with progestin-containing oral contraceptives may reduce the efficacy of the contraceptive. The effect of progestin-only contraceptives on the efficacy of ORILISSA is unknown. Coadministration of ORILISSA with progestin-containing intrauterine contraceptive systems has not been studied.

    ADVERSE REACTIONS

    • The most common adverse reactions (>5%) in clinical trials included hot flushes and night sweats, headache, nausea, insomnia, amenorrhea, anxiety, arthralgia, depression-related adverse reactions, and mood changes.

    These are not all the possible side effects of ORILISSA.

    Safety and effectiveness of ORILISSA in pediatric patients have not been established.

    US-ORIL-210045