See ORILISSA in action

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What is ORILISSA?

ORILISSA is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if ORILISSA is safe and effective in children.

Individual results may vary.

Please see Use and Important Safety Information for ORILISSA at the end of this video.

Please see Full Prescribing Information, including Medication Guide for ORILISSA, on Orilissa.com.

Do not take ORILISSA if you:

Are pregnant, have osteoporosis, have severe liver disease, are taking medicines called OATP 1B1 inhibitors that are known or expected to significantly increase the blood levels of elagolix, the active ingredient in ORILISSA (ask your HCP if you are not sure if you are taking one of these medicines), or have had a serious allergic reaction to ORILISSA or any of the ingredients in ORILISSA. See the end of the Medication Guide for a complete list of ingredients in ORILISSA. Ask your HCP if you are not sure.

Please see additional Important Safety Information and the Full Prescribing Information, including Medication Guide, on this website.

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To understand how ORILISSA works, it helps to know how endometriosis affects your body.

For women with endometriosis, tissue similar to the lining of the uterus–called endometrium–grows outside of the uterus, where it doesn’t belong, forming lesions.

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uterus

ovary

endometrium

lesion

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These lesions are fueled by a hormone called estrogen.

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estrogen

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During your menstrual cycle, when estrogen levels rise, these lesions can grow. And later, during your period, the lesions can break down and shed. This can cause pain throughout the month. One way to manage common symptoms of endometriosis is to reduce the amount of estrogen your body produces. ORILISSA works like this, leading to a reduction of estrogen. ORILISSA is an oral pill for women with moderate to severe endometriosis pain. It works in the pituitary gland,

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pituitary gland

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which is located at the base of the brain. In the pituitary gland, a hormone called GnRH activates receptors

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GnRH

Gonadotropin-Releasing Hormone

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that set off a chain reaction of signals that tell your ovaries to produce hormones such as estrogen.

ORILISSA does not contain hormones. It is a GnRH receptor blocker,

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pituitary gland

GnRH

receptor blocker

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which means that it blocks GnRH from activating some of these receptors, so it leads to less estrogen being produced. How? Think of it like a game of musical chairs. The chairs represent your GnRH receptors,

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GnRH receptors

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and the women in blue represent GnRH.

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GnRH

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In order to send signals to your ovaries to produce estrogen, GnRH needs to attach to your receptors just like the women in blue try to sit in a chair. Here’s where ORILISSA steps in.

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ORILISSA logo

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When ORILISSA joins in on the game of musical chairs, it takes up some of the seats. So there are fewer seats available for GnRH. When GnRH molecules are blocked, they can’t activate receptors, and not as many signals can be sent to the ovaries telling them to produce estrogen. When less estrogen is produced, there is less fuel for the endometrial lesions. And that’s how ORILISSA works. To find out if ORILISSA is right for you, talk to your gynecologist. Share this video with the women in your life who have endometriosis.

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SAFETY CONSIDERATIONS

Do not use ORILISSA if you are pregnant, have osteoporosis or severe liver disease, take medicines called organic anion transporting polypeptide (OATP) 1B1 inhibitors that are known or expected to significantly increase the blood levels of elagolix (the active ingredient in ORILISSA), or have had a serious allergic reaction to ORILISSA or any of the ingredients in ORILISSA. ORILISSA does not prevent pregnancy. It may alter your period, so watch for other signs of pregnancy. Stop taking ORILISSA if you become pregnant. Ask about proper birth control, as some may affect how ORILISSA works. ORILISSA may affect how some birth control works. ORILISSA can cause serious side effects, including bone loss, abnormal liver tests, suicidal thoughts or behaviors, and worsening mood. Talk to your healthcare provider right away if you notice changes such as jaundice, dark amber-colored urine, suicidal thoughts or actions, depression, or worsening mood.

Please see additional Important Safety Information and the Full Prescribing Information, including Medication Guide, on this website.

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