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What is ORILISSA?
ORILISSA is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if ORILISSA is safe and effective in children.

Do not take ORILISSA if you:
Are pregnant, have osteoporosis, have severe liver disease, are taking medicines called OATP 1B1 inhibitors that are known or expected to significantly increase the blood levels of elagolix, the active ingredient in ORILISSA (ask your HCP if you are not sure if you are taking one of these medicines), or have had a serious allergic reaction to ORILISSA or any of the ingredients in ORILISSA. See the end of the Medication Guide for a complete list of ingredients in ORILISSA. Ask your HCP if you are not sure.

Please see additional Important Safety Information and the Full Prescribing Information, including Medication Guide, on this website.

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Dr. Shepherd’s ORILISSA STORY

Individual results may vary.

DR. SHEPHERD:
I’m Dr. Shepherd. I’m a gynecologist who specializes in endometriosis management and I’m highly trained in excision surgery. Endometriosis presents itself in so many different ways and varying degrees from woman to woman. So the right way to manage endometriosis is going to be different for each patient. So, to determine what’s right, I usually start by building trust and establishing a really good relationship to get to know my patient better. I feel that’s really important. So I’ll ask about their medical history, I’ll ask about their symptoms, and their treatment goals. You know, I really want to make sure that they feel that they’re heard. And then we come up with a treatment plan. Often times, surgery isn’t always what’s appropriate for a patient who has moderate to severe endometriosis pain. And I’ll recommend medical management instead. And so for those instances, I may recommend ORILISSA as an option for medical treatment.  

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Please see Important Safety Information and the Full Prescribing Information, including the Medication Guide, on this website.

DR. SHEPHERD:
You know, I explain to patients that endometriosis is a chronic condition and is fueled by estrogen, and ORILISSA works by dialing estrogen down. For my patients, I definitely make sure that I explain, as with any treatment, there may be side effects on ORILISSA. Everyone has a different experience with side effects, so I tell my patients to let me know if they have any of those. And if they have any concerns, to please come and see me so that we can address them. I find that at three months, when I have my patients come back in for a scheduled follow-up, that they do have improvement in their pain after starting ORILISSA. So, have that conversation about ORILISSA with your gynecologist and see if it could be right for you.

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ASK YOUR GYNECOLOGIST IF ORILISSA COULD BE RIGHT FOR YOU. 

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SAFETY CONSIDERATIONS

Do not use ORILISSA if you are pregnant, have osteoporosis or severe liver disease, take medicines called organic anion transporting polypeptide (OATP) 1B1 inhibitors that are known or expected to significantly increase the blood levels of elagolix (the active ingredient in ORILISSA), or have had a serious allergic reaction to ORILISSA or any of the ingredients in ORILISSA. ORILISSA does not prevent pregnancy. It may alter your period, so watch for other signs of pregnancy. Stop taking ORILISSA if you become pregnant. Ask about proper birth control, as some may affect how ORILISSA works. ORILISSA may affect how some birth control works. ORILISSA can cause serious side effects, including bone loss, abnormal liver tests, suicidal thoughts or behaviors, and worsening mood. Talk to your healthcare provider right away if you notice changes such as jaundice, dark amber-colored urine, suicidal thoughts or actions, depression, or worsening mood.

Please see additional Important Safety Information and the Full Prescribing Information, including Medication Guide, on this website.

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