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ORILISSA is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if ORILISSA is safe and effective in children under 18 years of age.

Do not take ORILISSA if you:

Are or may be pregnant, have osteoporosis, have severe liver disease, or take medicines known as strong OATP1B1 inhibitors, such as cyclosporine or gemfibrozil. 

Please see additional Important Safety Information and the Full Prescribing Information, including Medication Guide, on this website.

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Individual results may vary.

GILLIAN: My pain and trouble with my period started when I was 12. And as I got older, the pain got worse. It almost felt like a rake was just…tearing down the front of my uterus. I decided this isn’t right. I shouldn’t be in this kind of pain. Hi, I’m Gillian. And I have endometriosis. From my first painful period to endometriosis diagnosis, it took nine years. And it was a trying nine years. Because of my pain, I was having to take a lot of breaks. You know, I couldn’t walk for a long period of time, stand in line somewhere. You know, sit with friends. Honestly, I was in pain every day and being on my period was just something worse. So when my gynecologist first suggested I take ORILISSA, I was a little bit wary. Just because I was worried it was gonna be like some other treatments I had tried in the past. But she really took the time to sit down with me and explain what ORILISSA was. And I…felt better about my decision.


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Please see Important Safety Information and the Full Prescribing Information, including the Medication Guide, on this website. 

GILLIAN: After three months of taking ORILISSA, I was in less pain. That cramping feeling had lessened. That every day pain had decreased. I was out shopping with my mom. And she's like, you know, “Do you need to take a break?" And I'm like, “No.” “Are you sure?” “Yeah! Like, I feel good. Let’s keep shopping.” You know, I wasn't having to say, like, you know, oh, I need a minute. Like, I need to wait for this, you know, cramp to subside. You know, then I was, like, okay, yeah, this—this works. On ORILISSA, I had less pain throughout the month. And I think that's a definite reason why…other women should give it a chance. It’s something worth trying. Do your own research. Don’t let other people dictate what treatment you should or shouldn’t take.


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Ask your gynecologist about ORILISSA 

GILLIAN: Talk to your doctor. Talk to your doctor about ORILISSA. See if it works for you.



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Do not use ORILISSA if you are or may be pregnant, have osteoporosis or severe liver disease, or take medicines such as cyclosporine or gemfibrozil. ORILISSA does not prevent pregnancy. It may alter your period, so watch for other signs of pregnancy. Stop taking ORILISSA if you become pregnant. Ask about proper birth control, as some may affect how ORILISSA works. ORILISSA can cause serious side effects, including bone loss, abnormal liver tests, suicidal thoughts or behaviors, and worsening mood. Talk to your healthcare provider right away if you notice changes such as jaundice, dark amber-colored urine, suicidal thoughts or actions, depression, or worsening mood. 

Please see additional Important Safety Information and the Full Prescribing Information, including Medication Guide, on this website.