[LOGO]

[Text on Screen]
What is ORILISSA?
ORILISSA is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if ORILISSA is safe and effective in children.

Individual results may vary.

[Text on Screen]
MEGHAN M.
CALIFORNIA

[Text on Screen]
Do not take ORILISSA if you:
Are pregnant, have osteoporosis, have severe liver disease, are taking medicines called OATP 1B1 inhibitors that are known or expected to significantly increase the blood levels of elagolix, the active ingredient in ORILISSA (ask your HCP if you are not sure if you are taking one of these medicines), or have had a serious allergic reaction to ORILISSA or any of the ingredients in ORILISSA. See the end of the Medication Guide for a complete list of ingredients in ORILISSA. Ask your HCP if you are not sure.

Please see additional Important Safety Information and the Full Prescribing Information, including Medication Guide, on this website.

[Text on Screen]
I USED TO BE

Meghan:
I used to be….

[Text on Screen]
NERVOUS

Meghan:
…nervous about…

Meghan:
…ORILISSA

[Text on Screen]
I DIDN’T KNOW

Meghan:
I didn’t know…

[Text on Screen]
WHAT TO EXPECT

Meghan:
…what to expect.

[Text on Screen]
LOOKED IT UP

Meghan:
So, I looked it up…

Meghan:
…on social media.

Meghan:
Everyone just commented about the negative.

Meghan:
I felt a little bit discouraged.

[Text on Screen]
BUT THEN I REALIZED

Meghan:
But then I realized…

Meghan:
…there was like a lot of…

[Text on Screen]
NEGATIVE

Meghan:
…negative…

[Text on Screen]
COMMENTS

Meghan:
…comments…

Meghan:
…of women that…

[Text on Screen]
HADN’T EVEN TRIED IT

Meghan:
…hadn’t even tried it.

Meghan:
That’s just how the internet is.

Meghan:
People hide behind their computer screens or nowadays their

Meghan:
…phone screens, and…

[Text on Screen]
JUST NEGATIVE

Meghan:
…they’re just negative. I realized…

Meghan:
…ORILISSA was something

[Text on Screen]
GYNECOLOGIST RECOMMENDED

Meghan:
…my gynecologist had recommended…

[Text on Screen]
ENDOMETRIOSIS PAIN

Meghan:
…for my endometriosis pain.

[Text on Screen]
Please see additional Important Safety Information and the Full Prescribing Information, including Medication Guide, on this website.

Meghan:
He was hopeful that it would…

[Text on Screen]
Please see additional Important Safety Information and the Full Prescribing Information, including Medication Guide, on this website.

Meghan:
…work for me, and I trust him.

[Text on Screen]
Please see additional Important Safety Information and the Full Prescribing Information, including Medication Guide, on this website.

Meghan:
So, I just decided to put the…

[Text on Screen]
NAYSAYERS ASIDE

Meghan:
…naysayers aside…

Meghan:
…and go for it.

[Text on Screen]
I HAD TO TRY ORILISSA^® (elagolix)

Meghan:
I had to try ORILISSA…

[Text on Screen]
FOR MYSELF

Meghan:
…for myself.

Meghan:
Turns out…

Meghan:
…ORILISSA is working for me.

[Text on Screen]
I HAVE RELIEF

Meghan:
I just have relief with ORILISSA and…

Meghan:
…I’m very grateful for that.

Meghan:
That’s why I asked if I could share my story.

[Text on Screen]
I WANT WOMEN TO KNOW

Meghan:
I want women to know that…

Meghan:
…they deserve to feel relief.

Meghan:
I can’t tell you that ORILISSA is gonna work for you…

[Text on Screen]
IT’S WORTH A TRY

Meghan:
…but it’s worth a try…

Meghan:
…because there’s women out there…

Meghan:
…that ORILISSA works for.

Meghan:
Now that I know what ORILISSA is really like…

[Text on Screen]
I’M ALL FOR IT

Meghan:
…I’m all for it.

[Text on Screen]
THINKING ABOUT TRYING ORILISSA (elagolix)?

[Text on Screen]
TALK TO YOUR GYNECOLOGIST TO SEE IF IT COULD BE RIGHT FOR YOU.

[ORILISSA logo]

[Text on Screen/Voiceover]

SAFETY CONSIDERATIONS

Do not use ORILISSA if you are pregnant, have osteoporosis or severe liver disease, take medicines called organic anion transporting polypeptide (OATP) 1B1 inhibitors that are known or expected to significantly increase the blood levels of elagolix (the active ingredient in ORILISSA), or have had a serious allergic reaction to ORILISSA or any of the ingredients in ORILISSA. ORILISSA does not prevent pregnancy. It may alter your period, so watch for other signs of pregnancy. Stop taking ORILISSA if you become pregnant. Ask about proper birth control, as some may affect how ORILISSA works. ORILISSA may affect how some birth control works. ORILISSA can cause serious side effects, including bone loss, abnormal liver tests, suicidal thoughts or behaviors, and worsening mood. Talk to your healthcare provider right away if you notice changes such as jaundice, dark amber-colored urine, suicidal thoughts or actions, depression, or worsening mood.

Please see additional Important Safety Information and the Full Prescribing Information, including Medication Guide, on this website.

US-ORIL-210024